By Suna F. Kiraç
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Extra resources for Advances in the Diagnosis of Coronary Atherosclerosis
Found a tendency for serum TRAIL levels to be lower in patients with coronary artery disease (CAD) compared with subjects without CAD, although this difference was not significant. To further investigate this relationship, we examined serum TRAIL levels in 285 subjects who underwent coronary angiography for suspected CAD. , 2010). , 2010). , 2010). Taken together, these results suggest that lower TRAIL levels may reflect the advancement of CAD. In addition to cross-sectional findings, recent studies have also suggested that TRAIL can be a protective predictor against cardiovascular prognosis.
It is necessary to investigate how TRAIL is produced and cleared in humans in future studies. In addition, to confirm the direct effects of TRAIL on cardiovascular diseases, administration of recombinant TRAIL may be a powerful approach. , 2004). Further studies are needed to address these problems. 4. Acknowledgment This review was supported in part by a Grant-in-Aid for scientific research (No. 20591068) from the Japan Society for the Promotion of Science (to ME and KM). The authors thank Dr.
2002), although this is not the case in vascular cells. , 2000). In clinical studies, use of various medications against diabetes, hypertension, dyslipidemia, and so on is often unavoidable. To interpret the association between TRAIL and cardiovascular lesions, it is important to pay attention to the types of interventions used. 5 TRAIL as a possible biomarker in early atherosclerotic lesions As noted above, lower TRAIL levels appear to be correlated with more severe cardiovascular lesions and poorer prognosis.
Advances in the Diagnosis of Coronary Atherosclerosis by Suna F. Kiraç