By Loretta Dorstyn, Makoto Kinoshita (auth.), Dr. Sharad Kumar (eds.)
The previous few years have obvious quick development in apoptosis study. This quantity offers with a few of the fresh advances made in uncovering the molecular and mobile foundation of apoptosis and elaborates on how this amassing wisdom helps us to appreciate the importance of apoptosis in pathogenesis of ailments coming up from beside the point mobile loss of life. additional, mechanistic elements of mobile demise and position of apoptosis in affliction is roofed.
The articles released during this quantity are written by means of top specialists within the box and may be a necessary source for researchers in biomedicine and melanoma research.
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Additional info for Apoptosis: Mechanisms and Role in Disease
1993; Su et al. 1993) and to microtubules (Munemitsu et al. 1994; Smith et al. 1994). The growth of human colorectal cancer cells lacking APC can be inhibited by expression of APC in an inducible expression system. This was shown to occur by induction Proteolytic Targets in Cell Death 37 of apoptosis (Morin et al. 1996). During apoptosis APC is cleaved to a 90-kDa fragment (Browne et al. 1994). The function of this protein and how its cleavage is important for apoptosis are not understood at present.
An exampie of cross-dass inhibition. J Biol Chem 269:19331- 19337 Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS-S, Flavell RA (1995) Altered cytokine export and apoptosis in mice deficient in int erleukin-Ibeta conv erting enzyme. Seien ce 267:2000-2003 Kuida K, Zheng TS, Na S, Kuan C-Y, Yang D, Karasuyama H, Rakic P, Flavell RA (1996) Decreased apoptosis in the brain and prem ature lethality in CPP32-defieient mice. Nature 384:368-372 Kumar S (1995) ICE-like cystein e proteases in apoptosis.
The importance of proteases in the execution of apoptosis has become increasingly apparent, in particular the cysteine proteases of the interleukin lß-converting enzyme (ICE)-like family (caspases) (Martin and Green 1995; Kumar and Lavin 1996) and the serine proteases of the granzyme B family (Greenberg 1996). A role for calpain (Squier and Cohen 1996) and the proteasome has also been described (Grimm et al. 1996). Caspases display an absolute requirement for aspartic acid at the PI position of their substrate (Alnemri et al.
Apoptosis: Mechanisms and Role in Disease by Loretta Dorstyn, Makoto Kinoshita (auth.), Dr. Sharad Kumar (eds.)