Download PDF by Jacqueline A. Reynolds (auth.), J. R. Harris, A.-H. Etémadi: Artificial and Reconstituted Membrane Systems

By Jacqueline A. Reynolds (auth.), J. R. Harris, A.-H. Etémadi (eds.)

ISBN-10: 1461393620

ISBN-13: 9781461393627

ISBN-10: 1461393647

ISBN-13: 9781461393641

This selection of eleven chapters is dedicated to a survey of synthetic and reconsti­ tuted membrane structures. those are basic subject matters and parts of serious present significance in membrane biochemistry. additionally they relate good to the founding notion of this sequence, specifically, to give reviews that gradually paintings towards and supply us with an "integrated view of the mobile. " during this quantity, it's the program of a variety of physiochemical and biochemi­ cal concepts to the research of membrane lipids and proteins which serves to illustrate the numerous development that has been made during this box over the last 25 years. From the certainty of simplified man made structures, it really is was hoping that it'll finally be attainable to realize a extra exact figuring out of common organic membranes, in all their variety. This ebook is a suitable successor to quantity thirteen of the sequence, which bargains with fluorescence reviews on organic membranes. certainly, the current bankruptcy through Lesley Davenport and co-workers was once initially due for inclusion in quantity thirteen, yet has been held over for inclusion during this quantity, the place it integrates remarkably good with the opposite issues. The tremendous various and engaging contents of this quantity at the moment are in brief defined. In bankruptcy I, Jacqueline A. Reynolds and Darrell R. McCaslin pres­ ent a pertinent survey of the interplay of detergents with membrane lipids and proteins, including an evaluate of the reconstitution process.

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Extra info for Artificial and Reconstituted Membrane Systems

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Factors Responsible for Determining Lipid Phase It is a general observation that some species of membrane lipid form one particular phase under a given set of conditions while another molecular species will form a different phase under the same conditions. A large amount of data have accumulated over the years on both lipids of natural origin as well as on pure synthetic materials which have helped to establish the principles on which the phase behavior of these membrane components depend. One way that the phase characteristics have been described is in terms of the so-called molecular shape concept.

Thus, apart from characteristic average structural properties of lipid-water phases, it is possible to derive rotational and translational diffusion coefficients and correlation times for molecular motions. In respect of the structural properties of these systems, information on the average conformation of the lipid acyl chains and polar head groups can be obtained as well as an indication of specific and nonspecific interactions between molecules in mixed lipid systems. An important parameter that can also be obtained is the order parameter that is a measure of the angular distribution of molecules about a preferred molecular orientation.

The form in which these lipids are found in excess water are micellar aggregates or a hexagonal-I type of structure. On the other hand, lipids with a smaller polar head group relative to the hydrocarbon chains are referred to as cone-shaped lipids and in excess water will tend to form inverted structures such as the hexagonal-II phase or inverted micellar structures. An intermediate lipid type, which is said to have a cylindrical structure, is where the cross-sectional area of the acyl chains is comparable to that of the polar head group of the molecules.

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Artificial and Reconstituted Membrane Systems by Jacqueline A. Reynolds (auth.), J. R. Harris, A.-H. Etémadi (eds.)


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